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Samsung Advanced Institute for Health Sciences and Technology (SAIHST) - Medical Device Management and Research

List KOR
  • Professor Neonatology
  • CHANG, YUN SIL

Research Interest 

Neonatal lung and brain injury
Mesenchymal stem cells
Extracelluar vesicles

Education

  • 1989 M.D., 1994 M.S., 1997 Ph.D. Seoul National University College of Medicine

Experience

  • 1989.03-1990.02 Internship in Seoul National University Hospital, Seoul, Korea
  • 1990.03-1994.02 Residency of Pediatrics, Seoul National University Children’s Hospital, Seoul, Korea
  • 1994.03 Korean Board of Pediatrics
  • 1994.03-1994.12 Fellowship of Neonatology Seoul National University Children’s Hospital, Seoul, Korea
  • 1995.01-1996.02 Fellowship of Neonatology Samsung Medical Center, Seoul, Korea
  • 1996.03-present Staff Neonatologist in Samsung Medical Center, Seoul, Korea
  • 1997.03-1999.03 Instructor of Pediatrics, Sungkyunkwan University School of Medicine, Seoul, Korea
  • 1999.04-2003.03 Assistant Professor of Pediatrics, Sungkyunkwan University School of Medicine, Seoul, Korea
  • 2003.04-2009.03 Associate Professor of Pediatrics, Sungkyunkwan University School of Medicine, Seoul, Korea
  • 2003.08-2004.08 Visiting Scholar in University of California, San Francisco eonatal brain lab (PI: Donna M. Ferriero)
  • 2009.04-present Professor of Pediatrics Sungkyunkwan University School of Medicine, Seoul, Korea
  • 2009.11-2013.10 Director, Committee for Data Collection and Statistics, Korean Society of Neonatology
  • 2012.03-present Professor, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Korea
  • 2013.03-2019.02 Secretary General, Executive Committee, Korean Neonatal Network (KNN)
  • 2013.09-2019.03 Chief of Science Committee, Stem Cell & Regenerative Medicine Institute, Samsung Medical Center, Seoul, Korea
  • 2013.11-2017.10 Editor in Chief, Neonatal Medicine(Official J of the Korean Society of Neonatology)
  • 2015.06-present Section Editor, Journal of Korean Medical Science (Korea)
  • 2016.03-present Editorial Board, Neonatology (Switzerland)
  • 2016.12-present Chief of Planning Committee, Korean Society of Perinatology
  • 2017.12-2019.12 Vice president Seoul and Kyungin tributary of Korean Society of Neonatology
  • 2019.03-present Director, Korean Neonatal Network (KNN)
  • 2019.04-present Director, Stem Cell & Regenerative Medicine Institute, Samsung Medical Center, Seoul, Korea
  • 2019.04-present Director, Maternal and Child Intensive Care Center, Samsung Medical Center, Seoul, Korea
  • 2020.10-present Editorial Board, Pediatric Medicine(PM)
  • 2021.1-present Chief of Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Korea

Journal Articles

  • (2023)  Homozygous SERPINC1 Mutation in Con genital Antithrombin Deficiency: A Unique First Case of Neonatal Cardiac Thrombosis.  Perinatology.  34,  4
  • (2023)  Nationwide Long-Term Growth and Developmental Outcomes of Infants for Congenital Anomalies in the Digestive System and Abdominal Wall Defects With Surgery in Korea.  JOURNAL OF KOREAN MEDICAL SCIENCE.  38,  49
  • (2023)  Antenatal magnesium sulfate is not associated with improved long-term neurodevelopment and growth in very low birth weight infants.  JOURNAL OF KOREAN MEDICAL SCIENCE.  38,  44
  • (2023)  Five-year follow-up of phase II trial of stromal cells for bronchopulmonary dysplasia.  THORAX.  78,  11
  • (2023)  Loop-mediated isothermal amplification assay for screening congenital cytomegalovirus infection in newborns.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY.  107,  22
  • (2023)  Mesenchymal Stromal Cells Primed by Toll-like Receptors 3 and 4 Enhanced Anti-Inflammatory Effects against LPS-Induced Macrophages via Extracellular Vesicles.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  24,  22
  • (2023)  Major Congenital Anomalies in Korean Livebirths in 2013–2014: Based on the National Health Insurance Database.  JOURNAL OF KOREAN MEDICAL SCIENCE.  38,  39
  • (2023)  Optimal Protocols and Management of Clinical and Genomic Data Collection to Assist in the Early Diagnosis and Treatment of Multiple Congenital Anomalies.  CHILDREN-BASEL.  10,  10
  • (2023)  Changes to Blood-Sampling Protocol to Reduce the Sampling Amount in Neonatal Intensive Care Units: A Quality Improvement Project.  JOURNAL OF CLINICAL MEDICINE.  12,  17
  • (2023)  Variations in medical practice of retinopathy of prematurity among 8 Asian countries from an international survey.  SCIENTIFIC REPORTS.  13,  1
  • (2023)  The Multifaceted Clinical Characteristics of Congenital Cytomegalovirus Infection: From Pregnancy to Long-Term Outcomes.  JOURNAL OF KOREAN MEDICAL SCIENCE.  38,  32
  • (2023)  Microbiologic Epidemiology of Early-onset Sepsis in Neonates Born at ≥35 0/7 Weeks' Gestation in Korea During 2009-2018.  PEDIATRIC INFECTIOUS DISEASE JOURNAL.  42,  8
  • (2023)  SOCS3 Protein Mediates the Therapeutic Efficacy of Mesenchymal Stem Cells against Acute Lung Injury.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  24,  9
  • (2023)  Corrigendum to Association Between Retinopathy of Prematurity in Very-Low-Birth-Weight Infants and Neurodevelopmental Impairment. Am J Ophthalmol 2022;244;205–215.  AMERICAN JOURNAL OF OPHTHALMOLOGY.  248,  1
  • (2023)  Stem cells for neonatal brain injury – Lessons from the bench.  SEMINARS IN PERINATOLOGY.  47,  3
  • (2023)  Clinical Outcome of Ultrasound-Detected Perforated Necrotizing Enterocolitis without Radiographic Pneumoperitoneum in Very Preterm Infants.  JOURNAL OF CLINICAL MEDICINE.  12,  5
  • (2023)  Comprehensive Evaluation of the NeoBase 2 Non-derivatized MSMS Assay and Exploration of Analytes With Significantly Different Concentrations Between Term and Preterm Neonates.  ANNALS OF LABORATORY MEDICINE.  43,  2
  • (2023)  Impact of time to full enteral feeding on long-term neurodevelopment without mediating by postnatal growth failure in very-low-birth-weight-infants.  SCIENTIFIC REPORTS.  13,  1
  • (2023)  Conservative Management of Patent Ductus Arteriosus Is Feasible in the Peri-Viable Infants at 22-25 Gestational Weeks.  BIOMEDICINES.  11,  1
  • (2022)  Neonatal Intensive Care Quality Level-Dependent Variations in the Survival Rate of Infants with a Birth Weight of 500 g or Less in Korea: A Nationwide Cohort Study.  NEONATOLOGY.  1,  1

Publications

  • (2016)  산과마취학.  군자출판사.  Lead author
  • (2011)  공용 심폐소생술 가이드라인의 개발 및 배포.  보건복지부,중앙응급의료센터,국립중앙의료원,대한심폐소생협회.  Co-author
  • (2008)  신생아 진료 지침 제 2판.  광문출판사.  Co-author
  • (2003)  신생아 집중 치료 지침서.  광문출판사.  Co-author
  • (1998)  신생아 보조 환기요법.  광문출판사.  Co-author

Patent/Intellectual Property

  • 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 만성폐질환 치료용 조성물(Compositions for Treating Chronic Lung Diseases Comprising Exosome Derived from Stem Cell Treated with Thrombin).  2018-551233.  20201117.  JAPAN
  • 기관지 폐 이형성증 (BPD) 예방 또는 치료용 물질 스크리닝 방법(Method for screening substances for the prevention or treatment of bronchopulmonary dysplasia (BPD)).  10-2173-6730000.  20201028.  KOREA, REPUBLIC OF
  • WKYMVm 펩타이드를 유효성분으로 포함하는 과산소성 폐질환의 예방 또는 치료용 조성물 (composition for preventing or treating hyperoxia-induced lung injury comprising WKYMVm peptide as an active ingredient).  16/207,441.  20200908.  UNITED STATES
  • 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 만성폐질환 치료용 조성물(Compositions for Treating Chronic Lung Diseases Comprising Exosome Derived from Stem Cell Treated with Thrombin).  16/091,656.  20200728.  UNITED STATES
  • 줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌혈관 질환 치료용 약학적 조성물.  14868825.2.  20200415.  EU
  • 줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌혈관 질환 치료용 약학적 조성물.  14868825.2.  20200415.  GERMANY
  • 트롬빈을 이용한 줄기세포 유래 엑소좀의 생성 촉진 방법.  14869537.2.  20200219.  EU
  • WKYMVm 펩타이드를 유효성분으로 포함하는 과산소성 폐질환의 예방 또는 치료용 조성물.  10-2017-0164880.  20191010.  KOREA, REPUBLIC OF
  • 신생아 ＨＩＥ 치료용 조성물.  10-2017-0142236.  20190422.  KOREA, REPUBLIC OF
  • 줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌혈관 질환 치료용 약학적 조성물(Pharmaceutical composition for treating cerebrovascular diseases, containing stem cell-derived exosome as active ingredient).  15103663.  20190101.  UNITED STATES
  • 트롬빈을 이용한 줄기세포 유래 엑소좀의 생성 촉진 방법 (Method for promoting generation of stem cell-derived exosome by using thrombin).  15/103,726.  20180529.  UNITED STATES
  • 트롬빈을 이용한 줄기세포 유래 엑소좀의 생성 촉진 방법.  2016-539061.  20180525.  JAPAN
  • 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 피부상처 치료용 조성물(Compositions for Treating Skin Wound Comprising Exosome Derived from Stem Cell Treated with Thrombin).  10-2017-0080366.  20180515.  KOREA, REPUBLIC OF
  • 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 만성폐질환 치료용 조성물(Compositions for Treating Chronic Lung Diseases Comprising Exosome Derived from Stem Cell Treated with Thrombin).  10-2016-0046197.  20180323.  KOREA, REPUBLIC OF
  • Method for treating an inflammatory brain disease comprising administering a stem cell-derived exosome (줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌염증성 질환의 치료용 조성물).  15/126,053.  20180320.  UNITED STATES
  • 줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌염증성 질환의 치료용 조성물.  2016-557971.  20180223.  JAPAN
  • 줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌혈관 질환 치료용 약학적 조성물.  2016-539062.  20170810.  JAPAN
  • Composition for treating intraventricular hemorrhage in preterm infants comprising mesenchymal stem cells.  13/655,356.  20170110.  UNITED STATES
  • Meothod of treating lung diseases using cells separated or proliferated from umbilical cord blood.  12/184,695.  20161122.  UNITED STATES
  • Composition for treating developmental and/or chronic lung diseases comprising cells separated or proliferated from umbilical cord blood.  제 2,640,728 호.  20161018.  CANADA

Honors / Awards

  • 2020.10 Sokcheon Research Award from Korean Society of Pediatrics for an annual distinct published article
  • 2001.10 Sokcheon Research Award from Korean Society of Pediatrics for an annual distinct research proposal
  • 2007.10 Nam Yang Research Award from Korean Society of Neonatology for a distinct article among nationally published article
  • 2011.10 Maeil Jinam Research Award from Korean Society of Neonatology for a distinct article among internationally published article
  • 2012.12 Nam Yang Research Award from Korean Society of Perinatology for a distinct article among internationally published article
  • 2014.10 Sokcheon Research Award from Korean Society of Pediatrics for an annual distinct published article
  • 2015.10 Nam Yang Research Award from Korean Society of Neonatology for a distinct article among nationally published article
  • 2019.10 Maeil Achievement Award from the Korean Society of Neonatology
  • 2020.12 Commendation of Minister of Health and Welfare from Commendation for the Promotion Healthcare Technology
  • 2020.12 Commendation of Prime Minister from Ministry of the Interior and Safety

Conference Paper

  • (2023)  고위험산모-신생아 지역센터 운영의 현안과 해결 방안.  강원대학교병원 신생아집중치료지역센터 제1회 심포지엄.  KOREA, REPUBLIC OF
  • (2023)  KNN Overview.  제6회 KNN Symposium 2023.  KOREA, REPUBLIC OF
  • (2023)  A case of cyclopia, alobar holoprosencephaly with arrhinia who survived till 9 months of life without aggressive life support.  제73차 대한소아청소년과학회 추계학술대회 초록집.  KOREA, REPUBLIC OF
  • (2023)  Agenesis of corpus callosum in a Noonan syndrome patient with PTPN11 mutation.  제73차 대한소아청소년과학회 추계학술대회 초록집.  KOREA, REPUBLIC OF
  • (2023)  Five-year follow-up of phase 2 trial of stromal cells for bronchopulmonary dysplasia.  제73차 대한소아청소년과학회 추계학술대회 초록집.  KOREA, REPUBLIC OF
  • (2023)  Utility of Whole Genome Sequencing(WGS) in infants Under One Year with Multiple Anomalies after Karyotyping or Chromosomal Microarray: A Prospective Study.  제73차 대한소아청소년과학회 추계학술대회 초록집.  KOREA, REPUBLIC OF
  • (2023)  극소 저체중 출생아에서 요도하열 환자의 임상적 특성과 자궁내 성장지연과의 관련성.  제73차 대한소아청소년과학회 추계학술대회 초록집.  KOREA, REPUBLIC OF
  • (2023)  극소미숙아에서 항생제 사용이 장내 마이크로바이옴 발달에 미치는 영향.  제73차 대한소아청소년과학회 추계학술대회 초록집.  KOREA, REPUBLIC OF
  • (2023)  극소저체중출생아에서 후기 폐동맥 고혈압의 위험 인자로서 초기 폐동맥 고혈압.  제73차 대한소아청소년과학회 추계학술대회 초록집.  KOREA, REPUBLIC OF
  • (2023)  선천성 고인슐린성 저혈당증을 동반한 가부키 증후군: 신생아 2예1.  제73차 대한소아청소년과학회 추계학술대회 초록집.  KOREA, REPUBLIC OF
  • (2023)  임상경과가 양호하였던 일측성 폐무형성증 조산아 1례.  제73차 대한소아청소년과학회 추계학술대회 초록집.  KOREA, REPUBLIC OF
  • (2023)  한국의 재태연령 32-35주 신생아에서 팔리비주맙 예방요법의 비용대비 효과 분석.  제73차 대한소아청소년과학회 추계학술대회 초록집.  KOREA, REPUBLIC OF
  • (2023)  Five-year follow-up of phase 2 trial of stromal cells for bronchopulmonary dysplasia.  PAS 2023 (Pediatric Academic Society).  UNITED STATES
  • (2023)  Prognostic factors for perinatal bacterial transmission from colonized mother to delivered VLBWI.  PAS 2023 (Pediatric Academic Society).  UNITED STATES
  • (2023)  Protective effect of BDNF-overexpressing Wharton’s Jelly-derived mesenchymal stem cells in severe intraventricular hemorrhage in newborn rats.  PAS 2023 (Pediatric Academic Society).  UNITED STATES
  • (2023)  Short- and long-term outcomes of surviving infants following intrauterine co-twin or co-triplet fetal death among Very- Low- Birth- Weight Infants in Korea Neonatal Network: A prospective cohort study from 2013 to 2020.  PAS 2023 (Pediatric Academic Society).  UNITED STATES
  • (2023)  신생아 와래에서 흔희 보나 감별이 필요한 질환.  Ambulatory Pediatrics 2023.  KOREA, REPUBLIC OF
  • (2022)  KNN 10년의 성과.  Korean Neonatal Network 10th Anniversary Symposium.  KOREA, REPUBLIC OF
  • (2022)  국민건강보험자료를 이용한 2013-2014년 한국 주요선천성기형 연구.  제72차 대한소아청소년과학회 추계학술대회 초록집.  KOREA, REPUBLIC OF
  • (2022)  출생 체중이 소아의 성장, 발달 및 의료비에 미치는 영향: 전국 코호트 연구.  제72차 대한소아청소년과학회 추계학술대회 초록집.  KOREA, REPUBLIC OF